|
KMID : 0616120110420010027
|
|
Korean Journal of Pharmacognosy
2011 Volume.42 No. 1 p.27 ~ p.31
|
|
|
Cognitive Enhancing Effect of Saponin Rich Fraction from the Roots Extract of Platycodon grandiflorum in Mice
|
|
Cha Mi-Ran
Choi Chun-Whan
Yoo Dae-Seok
Choi Yeon-Hee
Park Byoung-Keun
Kim Eun-Ju
Kim Young-Sup
Kang Jong-Seong
Kim Young-Ho
Ryu Shi-Yong
|
|
|
Abstract
|
|
|
|
The ameliorating effect of the saponin rich fraction (SRF) prepared from the roots extract of Platycodon grandiflorum (Campanulaceae) on the scopolamine-induced cognitive dysfunction in mice were investigated by way of Moris water maze task. The mice with repeated oral administration of the SRF for four weeks showed markedly reduced the swimming time and swimming distance to reach the platform as well as the increase of number of crossing the platform on the Moris water maze task performed after scopolamine intoxication. The results suggest that SRF obtained from the roots extract of P. grandiflorum exert a cognitive enhancing effect on scopolamine-induced memory impairment in mice.
|
|
|
KEYWORD
|
|
|
Platycodon grandiflorum, Campanulaceae, Saponin rich fraction (SRF), Cognitive dysfunction, Morris water maze
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|